Henrik Larsson, Teddy Sheringham, Dwight Yorke and Ole Gunnar Solskjaer will also take part in the Celtic v Manchester United legends clash at Celtic Park, which is being played to raise funds for Oxfam's East Africa Famine Appeal.
United legend Keane, who played for Celtic for a season at the end of his career before turning to football management, will take to the field the day before his 40th birthday.
And as well as playing alongside former team-mates, Keane will also take to the field alongside celebrities including boxer Ricky Hatton, musician Richard Ashcroft and comedian Angus Deayton.
Celtic legend Larsson is relishing a return to the club where he spent some of the best years of his career.
"It will be a tremendous pleasure to return to Celtic Park and play in this charity match in front of the best fans in the world," he said.
"I played for seven incredible years in Glasgow and can't wait to get back and pull on the green and white Hoops once again."
Former Trinidad and Tobago striker Yorke has high expectations for the encounter, which kicks off at 7.45pm.
"This is shaping up to be a great game of football," he said.
"The Celtic team is a who's who of top legends and some very interesting celebs are making an appearance too. But just because this is a charity match doesn't mean we are coming up to make up the numbers.
"We have top Man United legends and a great squad of celebrities from music, film, TV and sport in our team, who can all play a bit. I know that Henrik always gets an amazing reception at Celtic Park and it's great that he's flying in for the game. It's going to be an amazing atmosphere up there"
5 - 2 CELTIC!!!!! WOOOP!
Larsson with his Hat Trick.
