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Windows XP
MouseKeys settings on Windows XP
Mouse keys are enabled on Windows XP by selecting the Control Panel from the Start Menu, selecting Accessibility Options, selecting Mouse, checking "Use MouseKeys," and clicking "Apply." An alternate way to enable mouse keys is to press Alt+Shift+NumLock, or pressing Shift 5 times, pressing Settings, and going to the Mouse tab. For additional settings, click "Settings." Check the box that says "Hold down Ctrl to speed up and Shift to slow down." This will enable the cursor jump. Players also may want to disable showing mouse keys status on the screen.
Windows Vista
Mouse key settings on Windows Vista
Mouse keys are enabled on Windows Vista by selecting the Control Panel from the Start Menu, selecting Ease of Access, selecting the Ease of Access Centre, clicking "Make the mouse easier to use", then clicking "Set up Mouse Keys". Check the boxes that say "Turn on Mouse Keys" and "Hold down Ctrl to speed up and Shift to slow down." This will enable the cursor jump.
Windows 7
Mouse keys setup in Windows 7
Mouse keys are enabled by going Start menu→Control Panel→Ease of Access Centre→Make the mouse easier to use. Check the box that says "Turn on Mouse Keys". Setting can be adjusted from the "Set up Mouse Keys" link below the check box.
Mac OS X 10.3
Mouse keys setup in Mac OS X 10.3
To turn on Mouse Keys, click the System Preferences icon on the Dock, and then click the Universal Access icon. Select the Mouse & Trackpad pane, and turn on Mouse Keys.
5 clicks the mouse, and the surrounding eight number keys are used to move the cursor.
0 clicks and holds the cursor.
. Releases the cursor if it has been held by pressing 0.
Mac OS X 10.6
Mouse keys setup in Mac OS X 10.6
To turn on Mouse Keys, click the System Preferences icon on the Dock, and then click the Universal Access icon. Select the Mouse pane, and turn on Mouse Keys.
5 clicks the mouse, and the surrounding eight number keys are used to move the cursor.
0 clicks and holds the cursor.
. Releases the cursor if it has been held by pressing 0.
Didn't include the linux (GNOME) one because highly doubt anybody uses that OS. Taken from RSWIKI