What like?

Any application related settings based on user accounts wont work, desktop customizations (i.e themes, backgrounds, windows explorer settings) , anything that writes to the HKEY_CURRENT_USER wont work properly to list a few.
Well, you can deploy Windows Update patches via WSUS (Windows Server Update Services) which is a free product, although unless you have a large amount of client PCs it might just be best to ensure automatic updates are enabled and just let it do itself.
If you want to deploy programs, as long as they have a MSI installation package you can deploy them via group policy.
When it comes to antivirus updates/policy enforcing i'd highly recommend McAfee ePolicy Orchestrator (http://www.mcafee.com/uk/enterprise/...hestrator.html). I can personally recommend this as I currently use it on my network. It integrates with Active Directory and can automatically deploy specific products to current and all newly added workstations and servers along with remote configuration of settings, schedules, reporting, etc.
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