Defragging won't help this issue, neither will disk cleanup.

Some webpages you visit could be the cause of the problem, especially ones which use various active x plugins.
Could you do a print screen of the problem, Ive got a hunch what it is, but i am not 100% sure if i am having the same problem as you, if it is i know how to fix
As I still beleive - its from a windows display setting - for example the top bar of your browser and windows can apparently be different colours depending on what windows appearance settings you use.
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