Gary Neville and Rafael da Silva have been passed fit for United, while Wayne Rooney and Michael Carrick should recover from knocks in time to play.
Paul Scholes, Park Ji-sung and Carlos Tevez are among those likely to start.
Everton manager David Moyes must decide whether to risk striker Louis Saha, who has had a stomach virus.
On-loan striker Jo is cup-tied but Joseph Yobo and James Vaughan have recovered from injuries and are included in Moyes' squad.
Man Utd (from): Van der Sar, Foster, Kuszczak, Neville, Evra, Ferdinand, Vidic, Rafael, Fabio, O'Shea, Evans, Ronaldo, Anderson, Scholes, Fletcher, Gibson, Carrick, Park, Nani, Giggs, Rooney, Tevez, Berbatov, Macheda.
Everton (from): Howard, Hibbert, Lescott, Jagielka, Baines, Osman, Pienaar, Neville, Rodwell, Fellaini, Cahill, Yobo, Saha, Vaughan, Nash, Gosling, Jacobsen, Van der Meyde, Castillo, Baxter.
Glad Jo's cup-tied. Cahill, Saha, Osman and Fellaini are the main threats i think.